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A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection
Waters Corporation
We demonstrate the detection and identification of pesticide poisons ingested by a protected bird of prey. ACQUITY UPLC coupled with Xevo G2 QTof were used to screen samples suspected of pesticide poisoning and identify the pesticides used.
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Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave Based Ion Mobility Instrument Platforms
Waters Corporation
Here, we demonstrate through example of low molecular weight anti-cancer drugs and intact protein anti-cancer drug complexes, that the travelling-wave measured collision cross-sections are consistent between the SYNAPT HDMS and G2 platforms.
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RADAR - a Xevo TQ-S function - Combined with Low-High pH UPLC Screening For Fast Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
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Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
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Determination of Sulfonamide Antibiotics in Wastewater by LC / MS
Thermo Fisher Scientific
Sulfonamides are a common class of synthetic antimicrobials that are widely used in human and veterinary medicine and also as additives in animal feed. They are regarded as emerging environmental contaminants.
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A New Matrix Application Device for MALDI Tissue Imaging
Bruker Daltonics
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process.
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Multi-target Compound Analysis of Pesticides
Bruker Daltonik
Compared to classical approaches by triple quadrupole instruments, an ESI-TOF MS solution allows to screen a high number of targets within one LC-run and without the loss of sensitivity; it allows identification of unknown peaks based on accurate mass and isotopic pattern information (SigmaFit) while data can be archived and reprocessed later for additional compounds as well as data can be profiled for further statistical evaluation.
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The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
Thermo Fisher Scientific
It demonstrates several key performance features of the LCQ Fleet in the analysis of natural product extracts from cinnamon. Identification of multiple polyphenols in a single chromatographic analysis was achieved using the fast cycle time, high MSn sensitivity, PQD and High Resolution Isolation of the LCQ Fleet. In addition, simple data interpretation with Mass Frontier provides confident structural identification.
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A Quantitative Screen for Multiple Classes of Illicit Drugs and Their Primary Metabolites in Human Biological Fluids by LC-MS/MS
Thermo Fisher Scientific
Currently, GC/MS is the method of choice for quantifying drugs of abuse. In recent years, however, many forensic and toxicology labs have been switching to LC-MS/MS methods, which do not require time-consuming derivatization or extensive sample cleanup necessary in GC/MS analyses. Yet, many of the LC-MS/MS methods described in the literature either assay a limited number of illicit drug classes or do not include their primary metabolites of these illicit drugs.
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Analysis of Multiple Illicit Drugs, Methadone and their Metabolites in Oral Fluid using a Linear Ion Trap Mass Spectrometer
Thermo Fisher Scientific
A rapid and rugged LC-MS/MS method using the LXQ high-throughput linear ion trap is described for analyzing a mixture of twenty drugs and their metabolites using intelligent automated mass spectrometry (INTAMS). This method provides for the simultaneous identification and quantification of drugs and their metabolites.
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A High Throughput Approach for Metabolite Profiling and Characterization Using the LXQ Linear Ion Trap Mass Spectrometer
Thermo Fisher Scientific
A high throughput LC-MS/MS approach has been developed for metabolic profiling using the LXQ linear ion trap mass spectrometer. The rapid LC-MS/MS method made use of Data-Dependent™ acquisitions to study known metabolites and to uncover unexpected metabolites. The identification and characterization of glyburide along with 19 metabolites was accomplished in a single LC run of approximately three minutes using the fast cycle time, high sensitivity and excellent spectral quality of this instrument
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Collisionally-Induced Dissociation of Methimazole and Acetylsalicylic Acid: Proposed Mechanisms of Ion Formation using Hydrogen/Deuterium Exchange
Thermo Fisher Scientific, Pfizer PGRD
This application note demonstrates the utility of the TSQ Quantum Ultra AM for assessing the structures and mechanisms of Methimazole and Acetylsalicylic Acid in both negative and positive ion modes.
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Mechanisms of Ion Formation for Famotidine and Azithromycin using Hydrogen/Deuterium Exchange and High Resolution Mass Measurements
Thermo Fisher Scientific, Pfizer PGRD
This application note demonstrates the utility of the TSQ Quantum Ultra AM for assessing the structures and mechanisms of formation of principal fragment ions in the high-resolution CID mass spectra of famotidine and azithromycin.
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Testing LC-MS System Robustness with Automated Sample Cleanup Using Red Wine as a Matrix
Thermo Fisher Scientific
The goal of this note is to test the robustness of an LC-MS system for an automated online preconcentration system using a dirty matrix.
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LC/MS/MS Analysis of Anti-Infectives In Raw and Treated Sewage
Thermo Fisher Scientific, Université de Montréal, Centre Saint-Laurent
Describes development of a sensitive and robust method for the determination of some of the most prescribed anti-infectives in trace amounts (lower nanogram-per-liter range) in raw and treated wastewaters.
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