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Pharmacokinetics and Bioequivalence Evaluation of Erlotinib Hydrochloride Tablets: Randomized, Open-Label, 2-Period Crossover Study in Healthy Chinese Subjects.

A randomized, open-label, 2-period crossover study was performed to evaluate the pharmacokinetic properties and bioequivalence of 2 erlotinib hydrochloride tablets (a test formulation and a reference formulation) in healthy Chinese subjects. Subjects were randomized to receive a single oral dose of the erlotinib hydrochloride test or reference formulation (150 mg) under fasting conditions.

The washout period was 12 days. Blood samples were collected at scheduled time points, and plasma concentrations were determined using a high-performance liquid chromatography-tandem mass spectrometry method.

A noncompartmental method was used to calculate pharmacokinetic parameters and to evaluate the bioequivalence of the 2 formulations. Safety assessments were performed during the whole study period. The results suggest that the pharmacokinetic parameter values of the test formulation were similar to those of the reference formulation.

The 90% confidence intervals of the geometric least-squares mean ratios of the test to reference formulation were 94.06% to 105.43% for maximum concentration, 88.21% to 97.57% for area under the concentration-time curve to last measurement, and 87.37% to 97.14% for area under the curve extrapolated to infinity, which are all within the accepted bioequivalence range of 80% to 125%. No serious adverse events occurred during the study.

These findings suggest that the 2 erlotinib hydrochloride tablets were bioequivalent in accordance with predetermined regulatory criteria.

Alpha1-AGP/ Rat Alpha1- AGP ELISA Kit

ELA-E0816r 96 Tests
EUR 886

Bovine AGP ELISA Kit

E-10AGP 1 x 96 well plate
EUR 461

Rat AGP ELISA Kit

E-25AGP 1 x 96 well plate
EUR 441

Chicken AGP ELISA Kit

E-30AGP 1 x 96 well plate
EUR 441

Dog AGP ELISA Kit

E-40AGP 1 x 96 well plate
EUR 492

Human AGP ELISA Kit

E-80AGP 1 x 96 well plate
EUR 370

Human A1-AGP ELISA Kit

EHA0695 96Tests
EUR 521

Goat A1-AGP ELISA Kit

EGTA0695 96Tests
EUR 521

Canine A1-AGP ELISA Kit

ECA0695 96Tests
EUR 521

Chicken A1-AGP ELISA Kit

ECKA0695 96Tests
EUR 521

Anserini A1-AGP ELISA Kit

EAA0695 96Tests
EUR 521

Bovine A1-AGP ELISA Kit

EBA0695 96Tests
EUR 521

Mouse A1-AGP ELISA Kit

EMA0695 96Tests
EUR 521

Rat A1-AGP ELISA Kit

ERA0695 96Tests
EUR 521

Sheep A1-AGP ELISA Kit

ESA0695 96Tests
EUR 521

Rabbit A1-AGP ELISA Kit

ERTA0695 96Tests
EUR 521

Monkey A1-AGP ELISA Kit

EMKA0695 96Tests
EUR 521

Porcine A1-AGP ELISA Kit

EPA0695 96Tests
EUR 521

AGP ELISA Kit (Bovine) (OKCD06846)

OKCD06846 96 Wells
EUR 1040
Description: Description of target: Functions as transport protein in the blood stream.UniRule annotation;Species reactivity: Bovine;Application: ELISA;Assay info: ;Sensitivity: < 7.0ng/mL

Guinea Pig A1-AGP ELISA Kit

EGA0695 96Tests
EUR 521

Alpha 1 Acid Glycoprotein (A1-AGP), bovine

A1AG20-N 1 mg
EUR 164

Alpha 1 Acid Glycoprotein (A1-AGP), Rabbit

A1AG23-N-25 25 ug
EUR 286

Alpha 1 Acid Glycoprotein (A1-AGP), Turkey

A1AG24-N-100 100 ug
EUR 164

anti-α1-acid glycoprotein (AGP)(29A1)

LF-MA0167 100 ul
EUR 334
Description: Mouse monoclonal to α1-acid glycoprotein (AGP)

2-Propyl-β-D-glucuronide, 2 mg

0904-2 2 mg
EUR 162

Human ?1-Acid glycoprotein,?1-AGP ELISA Kit

201-12-1776 96 tests
EUR 440
  • This alpha 1-Acid glycoprotein ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human alpha-1-Acid-Glycoprotein (Orosomucoid, AGP) Antibody

32220-05111 150 ug
EUR 261

Human Alpha-1-Acid-Glycoprotein (Orosomucoid, AGP) Antibody

12011-05011 150 ug
EUR 217

Bovine α1-Acid glycoprotein,α1-AGP ELISA Kit

CN-00487B1 96T
EUR 458

Bovine α1-Acid glycoprotein,α2-AGP ELISA Kit

CN-00487B2 48T
EUR 307

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit

CN-01787R1 96T
EUR 473

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit

CN-01787R2 48T
EUR 323

Mouse α1-Acid glycoprotein,α1-AGP ELISA Kit

CN-02666M1 96T
EUR 464

Mouse α1-Acid glycoprotein,α1-AGP ELISA Kit

CN-02666M2 48T
EUR 313

Alpha 1 Acid Glycoprotein (A1-AGP), Human Plasma

A1AG15-N 1 mg
EUR 164

Mouse α1-AGP(α1-Acid glycoprotein) ELISA Kit

EM1448 96T
EUR 524.1
  • Detection range: 6.25-400 ng/ml
  • Alias: α1-AGP/ORM1/AGP/AGP1/AGPA/ORM1/Orosomucoid/AGP 1/AGP1/alpha-1-acid glycoprotein 1/AGP-A/OMD 1/ORM/orosomucoid 1/Orosomucoid-1/orosomucoid-1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 3.75 ng/ml

Rat α1-AGP(α1-Acid Glycoprotein) ELISA Kit

ER1432 96T
EUR 524.1
  • Detection range: 6.25-400 ng/ml
  • Uniprot ID: P02764
  • Alias: α1-AGP/ORM1/AGP/AGP1/AGPA/ORM1/Orosomucoid/AGP 1/AGP1/alpha-1-acid glycoprotein 1/AGP-A/OMD 1/ORM/orosomucoid 1/Orosomucoid-1/orosomucoid-1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 3.75 ng/ml

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E1792HM-48T 48T
EUR 289

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E1792HM-96T 96T
EUR 466

Porcine α1-Acid glycoprotein,α1-AGP ELISA Kit

GA-E0068PC-48T 48T
EUR 364

Porcine α1-Acid glycoprotein,α1-AGP ELISA Kit

GA-E0068PC-96T 96T
EUR 590

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E0093RT-48T 48T
EUR 317

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E0093RT-96T 96T
EUR 496

Porcine α1-AGP(α1-Acid Glycoprotein) ELISA Kit

EP0214 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Alias: Orosomucoid/OMD/Alpha-1-acid glycoprotein/Orm1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 0.094 ng/ml

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit

QY-E04459 96T
EUR 361

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

QY-E11560 96T
EUR 361

Mouse α1-Acid glycoprotein(α1-AGP)ELISA Kit

QY-E21637 96T
EUR 361

IL-2 Interleukin-2 Human Recombinant Protein, His Tag

PROTP60568-2 Regular: 10ug
EUR 317
Description: Interleukin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 133 amino acids fragment (21-153) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. _x000D_ The IL-2 His is purified by proprietary chromatographic techniques._x000D_

BMP-2 Bone Morphogenetic Protein-2 Human Recombinant Protein, Monomer

PROTP12643-2 Regular: 20ug
EUR 317
Description: Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 115 amino acids (283-396) and having a molecular mass of 13009 Dalton. ;The BMP-2 is purified by proprietary chromatographic techniques.

Individual Reaction Mix 2

G065-2 200 reactions
EUR 167

Anti-Fascin 2/FSCN2 Antibody

A07840-2 100ug/vial
EUR 294

Anti-EIF4A1/2/3 Antibody

A03922-2 100ug/vial
EUR 334

Anti-ErbB 2/ERBB2 Antibody

A00010-2 100ug/vial
EUR 334

Anti-Bcl-2/BCL2 Antibody

A00040-2 100ug/vial
EUR 334

Anti-Angiopoietin-2/ANGPT2 Antibody

A00370-2 100ug/vial
EUR 334

Dr. P Kit-Solution 2

K2021010-2 6 ml
EUR 120
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Recombinant Human TFF-2 Protein

PROTQ03403-2 20ug
EUR 317
Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma (Nikolaidis, N.M. et al. Am. Journal Respir. Cell Mol. Biol. (2003) 4: 458-464). Recombinant human TFF2 is a 12.0 kDa polypeptide of 107 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Recombinant Human BD-2 Protein

PROTO15263-2 20ug
EUR 317
Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.

Recombinant Human Relaxin-2 Protein

PROTP04090-2 25ug
EUR 317
Description: Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

Recombinant Murine IL-2 Protein

PROTP04351-2 20ug
EUR 317
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues.

Recombinant Human PAI-2 Protein

PROTP05120-2 10ug
EUR 317
Description: PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions. The physiological relevance of this property, which is neither a consequence of any mutation in the PAI-2 gene nor associated with any known disorder, is still unclear. However, it appears that the formation of intracellular dormant polymers may be important for the controlled release of the inhibitor from PAI-2 producing cells. Plasma levels of PAI-2 are usually low or undetectable, except during pregnancy and in some forms of monocytic leukemia. Secretion of PAI-2 from the placenta normally occurs during the third trimester of pregnancy and accounts for the dramatic increase in PAI-2 levels (up to 250 ng/ml), which are maintained at these levels until postpartum, and then rapidly decline. In addition to its vital role in protecting the placenta from degradation by uPA and/or uPA-activated proteases, PAI-2 has been shown to be essential for the prevention of metastatic spread of neck, lung and breast cancers. The beneficial effect of PAI-2 seen in these studies is presumed to stem from its ability to inhibit uPA-dependent cell dissemination. PAI-2 has also been reported to inhibit keratinocyte proliferation, and to participate in the innate immune response during viral infection. Recombinant human PAI-2 is a 415-residue nonglycosylated protein.

Recombinant Human MMP-2 Protein

PROTP08253-2 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids).

pLenti-CARM1 shRNA-2 Plasmid

PVTBAV03691-2 2 ug
EUR 356

pLenti-CTLA4 shRNA-2 Plasmid

PVTBAV05689-2 2 ug
EUR 356

pLenti-FOXM1 shRNA-2 Plasmid

PVTBAV08732-2 2 ug
EUR 356

pLenti-JUN shRNA-2 Plasmid

PVTBAV11741-2 2 ug
EUR 356

pLenti-LHX6 shRNA-2 Plasmid

PVTBAV12881-2 2 ug
EUR 356

pLenti-MAGEA3 shRNA-2 Plasmid

PVTBAV13661-2 2 ug
EUR 356

pLenti-RUNX3 shRNA-2 Plasmid

PVTBAV20583-2 2 ug
EUR 356

pLenti-Slc7a11 shRNA-2 Plasmid

PVTBAV21973-2 2 ug
EUR 356

pLenti-STAT3 shRNA-2 Plasmid

PVTBAV22921-2 2 ug
EUR 356

pLenti-XRCC5 shRNA-2 Plasmid

PVTBAV26238-2 2 ug
EUR 356

Mouse FGF-2 Recombinant Protein

R00121-2 5ug/vial
EUR 259
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast.

Chicken IL-2 Recombinant Protein

R00387-2 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Chicken IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

CLIA kit for Mouse ?1-AGP (?1-Acid glycoprotein)

E-CL-M0687 1 plate of 96 wells
EUR 584
  • Gentaur's ?1-AGP CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse ?1-AGP . Standards or samples are added to the micro CLIA plate wells and combined with
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Mouse ?1-AGP (?1-Acid glycoprotein) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat ?1-AGP (?1-Acid Glycoprotein)

E-CL-R0695 1 plate of 96 wells
EUR 584
  • Gentaur's ?1-AGP CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Rat ?1-AGP . Standards or samples are added to the micro CLIA plate wells and combined with th
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Rat ?1-AGP (?1-Acid Glycoprotein) in samples from Serum, Plasma, Cell supernatant

Alpha 1 Acid Glycoprotein (A1-AGP), Pig/Porcine/Swine

A1AG22-N-100 100 ug
EUR 164

Human Alpha-1-Acid Glycoprotein ELISA Kit (AGP 1)

RK00779 96 Tests
EUR 521

Chicken a1-Acid Glycoprotein (a-1-AGP) ELISA Kit

QY-E80114 96T
EUR 426

Anti-p56Dok-2 (Ab-299) Antibody

A07956-2 100ul
EUR 397
Description: Rabbit Polyclonal p56Dok-2 (Ab-299) Antibody. Validated in IF, IHC, WB and tested in Human.

Ethyl-β-D-glucuronide, 2 mg

0901-2 2 mg
EUR 162

Ethyl sulfate, sodium salt, 2 mg

0902-2 2 mg
EUR 69

Propyl-β-D-glucuronide, 2 mg

0903-2 2 mg
EUR 162

Anti-VEGF Receptor 2/KDR Antibody

A00901-2 100ug/vial
EUR 334

Anti-Adiponectin Receptor 2 (mouse) Antibody

A02218-2 200ug
EUR 498
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.

Anti-Anterior Gradient 2/AGR2 Antibody

A02922-2 100ug/vial
EUR 334

Anti-COX2/Cyclooxygenase 2/PTGS2 Antibody

A00084-2 100ug/vial
EUR 294

Anti-beta 2 Microglobulin/B2m Antibody

A00456-2 100ug/vial
EUR 294

Anti-HIF-2-alpha/EPAS1 Antibody

PA1129-2 100ug/vial
EUR 294

Anti-Bcl-2 Rabbit Monoclonal Antibody

M00040-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse.

ErbB2 ErbB-2 Human Recombinant Protein

PROTP04626-2 Regular: 20ug
EUR 317
Description: ErbB-2 Human Recombinant is a 43.4 kDa protein containing 397 amino acid residues of the human Herstatin, and an extra Methionine at N-Terminal (underlined), produced in E.coli.

Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82102 1 Kit Ask for price

Rat Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82597 1 Kit Ask for price

Human Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-96123 1 Kit Ask for price

Ethyl-β-D-glucuronide-d5, 2 mg

0901D-2 2 mg
EUR 386

Ethyl sulfate-d5, sodium salt, 2 mg

0902D-2 2 mg
EUR 92

Ethyl-β-D-glucuronide-13C6, 2 mg

0905-2 2 mg
EUR 366

Anti-Beta 2 Microglobulin Antibody (monoclonal, 2H10)

M00456-2 100ug/vial
EUR 334