3-Methylglutaconic (3MGC) aciduria is a typical phenotypic function of a rising quantity of inborn errors of metabolism. “Primary” 3MGC aciduria is attributable to deficiencies in leucine pathway enzymes whereas “secondary” 3MGC aciduria outcomes from inborn errors of metabolism that impression mitochondrial vitality manufacturing. The metabolic precursor of 3MGC acid is trans-3MGC CoA, an intermediate within the leucine catabolism pathway. Gas chromatography-mass spectrometry (GC-MS) evaluation of commercially out there trans-3MGC acid yielded a combination of cis and trans isomers whereas 1H-NMR spectroscopy of trans-3MGC acid at 25°C supplied no proof for the cis isomer.
When trans-3MGC acid was incubated beneath circumstances used for pattern derivatization previous to GC-MS (however with no trimethylsilane added), 1H-NMR spectroscopy supplied proof of trans to cis isomerization. Incubation of trans-3MGC acid at 37°C resulted in time-dependent isomerization to cis-3MGC acid. Cis-3MGC acid behaved in the same method besides that, beneath equivalent incubation circumstances, much less isomerization occurred. In settlement with these experimental outcomes, molecular modeling research supplied proof that the vitality minimized construction of cis-3MGC acid is four kJ/mol extra secure than that for trans-3MGC acid.
The knowledge introduced are according to the incidence of each diastereomers in urine samples of topics with 3MGC aciduria. Quantification of iron is a crucial step to evaluate the iron burden in sufferers affected by iron overload illnesses, in addition to super worth in understanding the underlying function of iron within the pathophysiology of these illnesses. Current iron willpower of complete or labile iron, requires in depth pattern dealing with and specialised devices, while being time consuming and laborious. Moreover, there’s minimal to no overlap between complete iron and labile iron quantification methodologies-i.e. requiring totally separate protocols, strategies and devices. Herein, we report a unified-ferene (u-ferene) assay that allows a 2-in-1 quantification of each labile and complete iron from the identical preparation of a organic specimen.
MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets
Site-specific proteolytic processing is a crucial, irreversible post-translational protein modification with implications in lots of illnesses. Enrichment of protein N-terminal peptides adopted by mass spectrometry-based identification and quantification allows proteome-wide characterization of proteolytic processes and protease substrates however is challenged by the shortage of particular annotation instruments. A typical downside is, for instance, ambiguous matches of recognized peptides to a number of protein entries within the databases used for identification.
We developed MaxQuant Advanced N-termini Interpreter (MANTI), a standalone Perl software program with an optionally available graphical consumer interface that validates and annotates N-terminal peptides recognized by database searches with the favored MaxQuant software program bundle by integrating data from a number of knowledge sources. MANTI makes use of numerous annotation data in a multistep determination course of to assign a conservative most well-liked protein entry for every N-terminal peptide, enabling automated classification in line with the doubtless origin and determines important adjustments in N-terminal peptide abundance. Auxiliary R scripts included within the software program bundle summarize and visualize key facets of the information.
To showcase the utility of MANTI, we generated two large-scale TAILS N-terminome knowledge units from two completely different animal fashions of chemically and genetically induced kidney illness, puromycin adenonucleoside-treated rats (PAN), and heterozygous Wilms Tumor protein 1 mice (WT1). MANTI enabled fast validation and autonomous annotation of >10 000 recognized terminal peptides, revealing novel proteolytic proteoforms in 905 and 644 proteins, respectively. Quantitative evaluation indicated that proteolytic actions with related sequence specificity are concerned within the pathogenesis of kidney harm and proteinuria in each fashions, whereas coagulation processes and complement activation have been particularly induced after chemical harm.
ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ
Previously, we recognized missense mutations in CCNF which can be causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Hallmark options of these illnesses embody the build-up of insoluble protein aggregates in addition to the mislocalisation of proteins reminiscent of TDP-43. In latest years, the dysregulation of SFPQ has additionally emerged as a pathological hallmark of ALS/FTD. CCNF encodes for the protein cyclin F, a substrate recognition part of an E3-ubiquitin ligase. We have beforehand proven that ALS/FTD-linked mutations in CCNF trigger disruptions to general protein homeostasis that results in a build-up of Ok48-linked ubiquitylated proteins in addition to defects in autophagic equipment.
To examine additional processes that could be affected by cyclin F, we used a protein-proximity ligation methodology, often known as BioID, customary immunoprecipitations and mass spectrometry (MS) to establish novel interplay companions of cyclin F and infer additional course of that could be affected by the ALS/FTD-causing mutation. Results display that cyclin F intently associates with proteins concerned with RNA metabolism in addition to a quantity of RNA binding proteins beforehand linked to ALS/FTD, together with splicing issue proline and glutamine wealthy (SFPQ).
Smad Interacting Protein 1 (ZEB2) (C-term) rabbit polyclonal antibody, Purified |
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AP31202PU-N | Origene Technologies GmbH | 50 µg | Ask for price |
Smad Interacting Protein 1 (ZEB2) (N-term) rabbit polyclonal antibody, Purified |
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AP31272PU-N | Origene Technologies GmbH | 50 µl | Ask for price |
Rabbit polyclonal antibody to NOSIP (nitric oxide synthase interacting protein) |
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TA308380 | Origene Technologies GmbH | 100 µl | Ask for price |
MLX interacting protein (MLXIP) (N-term) rabbit polyclonal antibody, Aff - Purified |
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AP52708PU-N | Origene Technologies GmbH | 400 µl | Ask for price |
Rabbit Polyclonal antibody to ARA9 (aryl hydrocarbon receptor interacting protein) |
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TA308832 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit polyclonal antibody to TOK-1 alpha (BRCA2 and CDKN1A interacting protein) |
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TA308557 | Origene Technologies GmbH | 100 µl | Ask for price |
Smad Interacting Protein 1 (ZEB2) (C-term) rabbit polyclonal antibody, Aff - Purified |
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AP54642PU-N | Origene Technologies GmbH | 400 µl | Ask for price |
Rabbit Polyclonal antibody to PPFIBP2 (PTPRF interacting protein, binding protein 2 (liprin beta 2)) |
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TA308142 | Origene Technologies GmbH | 100 µl | Ask for price |
RPA Interacting Protein Antibody |
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24482-100ul | SAB | 100ul | EUR 468 |
RPA Interacting Protein Antibody |
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24483-100ul | SAB | 100ul | EUR 468 |
RPA Interacting Protein Antibody |
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4013-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism. |
RPA Interacting Protein Antibody |
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4013-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism. |
RPA Interacting Protein Antibody |
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4015-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism. |
RPA Interacting Protein Antibody |
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4015-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism. |
Rpa Interacting Protein Antibody |
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20-abx115340 | Abbexa |
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RPA Interacting Protein Antibody |
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24482 | SAB | 100ul | EUR 479 |
RPA Interacting Protein Antibody |
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24483 | SAB | 100ul | EUR 479 |
Rabbit Polyclonal antibody to VCPIP1 (valosin containing protein (p97)/p47 complex interacting protein 1) |
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TA309036 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit polyclonal antibody to TNNI3K (TNNI3 interacting kinase) |
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TA308400 | Origene Technologies GmbH | 100 µl | Ask for price |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody |
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CAU23851-100ul | Biomatik Corporation | 100ul | EUR 229.4 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody |
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CAU23851-200ul | Biomatik Corporation | 200ul | EUR 287.3 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody |
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CAU23852-100ul | Biomatik Corporation | 100ul | EUR 222.7 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody |
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CAU23852-200ul | Biomatik Corporation | 200ul | EUR 278.9 |
Rabbit Polyclonal antibody to MID1IP1 (MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))) |
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TA309030 | Origene Technologies GmbH | 100 µl | Ask for price |
Polyclonal Antibody to Toll Interacting Protein (TOLLIP) |
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PAC803Hu01 | Cloud-Clone | 100ul | EUR 232 |
Polyclonal Antibody to Toll Interacting Protein (TOLLIP) |
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PAC803Mu01 | Cloud-Clone | 100ul | EUR 239 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human) |
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4-PAC803Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP) |
Polyclonal HSC70 Interacting Protein HIP (ST13) Antibody |
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APR16725G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HSC70 Interacting Protein HIP (ST13) . This antibody is tested and proven to work in the following applications: |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody |
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CAU22783-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody |
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CAU22783-200ul | Biomatik Corporation | 200ul | EUR 294 |
Fms interacting protein (FMIP) [domain 1] polyclonal antibody |
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ABP-PAB-11638 | Allele Biotech | 100 ug | Ask for price |
Fms interacting protein (FMIP) [domain 2] polyclonal antibody |
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ABP-PAB-11639 | Allele Biotech | 100 ug | Ask for price |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), PE |
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4-PAC803Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with PE. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), APC |
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4-PAC803Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with APC. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), Cy3 |
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4-PAC803Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with Cy3. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), HRP |
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4-PAC803Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with HRP. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody |
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CAU21098-100ul | Biomatik Corporation | 100ul | EUR 265.9 |
Description: polyclonal |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody |
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CAU21098-200ul | Biomatik Corporation | 200ul | EUR 332.6 |
Description: polyclonal |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody |
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CAU21099-100ul | Biomatik Corporation | 100ul | EUR 258.2 |
Description: polyclonal |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody |
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CAU21099-200ul | Biomatik Corporation | 200ul | EUR 322.6 |
Description: polyclonal |
Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) |
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PAE601Hu01 | Cloud-Clone | 100ul | EUR 245 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), FITC |
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4-PAC803Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with FITC. |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human) |
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4-PAE601Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2) |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse) |
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4-PAC803Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP) |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody |
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CAU21804-100ul | Biomatik Corporation | 100ul | EUR 255.4 |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody |
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CAU21804-200ul | Biomatik Corporation | 200ul | EUR 319.2 |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody |
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CAU21805-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody |
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CAU21805-200ul | Biomatik Corporation | 200ul | EUR 294 |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody |
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CAU22635-100ul | Biomatik Corporation | 100ul | EUR 241.9 |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody |
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CAU22635-200ul | Biomatik Corporation | 200ul | EUR 302.4 |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody |
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CAU22636-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody |
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CAU22636-200ul | Biomatik Corporation | 200ul | EUR 294 |
RPA Interacting Protein |
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20-abx262685 | Abbexa |
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Polyclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) |
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PAH763Ra01 | Cloud-Clone | 100ul | EUR 266 |
Polyclonal Antibody to Torsin A Interacting Protein 2 (TOR1AIP2) |
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PAR170Hu01 | Cloud-Clone | 100ul | EUR 269 |
Polyclonal Antibody to Torsin A Interacting Protein 2 (TOR1AIP2) |
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PAR170Mu01 | Cloud-Clone | 100ul | EUR 277 |
Thyroid receptor interacting protein 15 (TRIP15) polyclonal antibody |
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ABP-PAB-10139 | Allele Biotech | 100 ug | Ask for price |
Synuclein Alpha Interacting Protein 1 (SNCaIP1) Polyclonal Antibody |
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CAU23800-100ul | Biomatik Corporation | 100ul | EUR 255.4 |
Synuclein Alpha Interacting Protein 1 (SNCaIP1) Polyclonal Antibody |
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CAU23800-200ul | Biomatik Corporation | 200ul | EUR 319.2 |
Huntingtin Interacting Protein 1 Related Protein (HIP1R) Polyclonal Antibody |
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CAU24162-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Huntingtin Interacting Protein 1 Related Protein (HIP1R) Polyclonal Antibody |
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CAU24162-200ul | Biomatik Corporation | 200ul | EUR 294 |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human), PE |
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4-PAE601Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2). This antibody is labeled with PE. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat) |
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4-PAJ086Ra01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1) |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAC803Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with APC-Cy7. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse), APC |
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4-PAC803Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP). This antibody is labeled with APC. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse), Cy3 |
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4-PAC803Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP). This antibody is labeled with Cy3. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse), HRP |
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4-PAC803Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP). This antibody is labeled with HRP. |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse), PE |
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4-PAC803Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP). This antibody is labeled with PE. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human) |
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4-PAR170Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2) |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse) |
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4-PAR170Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2) |
Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) |
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PAE898Hu01 | Cloud-Clone | 100ul | EUR 245 |
Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) |
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PAE898Mu01 | Cloud-Clone | 100ul | EUR 252 |
Polyclonal Antibody to Fibrous Sheath Interacting Protein 1 (FSIP1) |
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PAJ086Hu01 | Cloud-Clone | 100ul | EUR 245 |
Polyclonal Antibody to Fibrous Sheath Interacting Protein 1 (FSIP1) |
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PAJ086Ra01 | Cloud-Clone | 100ul | EUR 266 |
Homeodomain Interacting Protein Kinase 2 (HIPK2) Polyclonal Antibody |
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CAU22482-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Homeodomain Interacting Protein Kinase 2 (HIPK2) Polyclonal Antibody |
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CAU22482-200ul | Biomatik Corporation | 200ul | EUR 294 |
Homeodomain Interacting Protein Kinase 1 (HIPK1) Polyclonal Antibody |
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CAU24161-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Homeodomain Interacting Protein Kinase 1 (HIPK1) Polyclonal Antibody |
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CAU24161-200ul | Biomatik Corporation | 200ul | EUR 294 |
Glutamate Receptor Interacting Protein 1 (GRIP1) Polyclonal Antibody |
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CAU25376-100ul | Biomatik Corporation | 100ul | EUR 222.7 |
Glutamate Receptor Interacting Protein 1 (GRIP1) Polyclonal Antibody |
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CAU25376-200ul | Biomatik Corporation | 200ul | EUR 278.9 |
Glutamate Receptor Interacting Protein 1 (GRIP1) Polyclonal Antibody |
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CAU25377-100ul | Biomatik Corporation | 100ul | EUR 222.7 |
Glutamate Receptor Interacting Protein 1 (GRIP1) Polyclonal Antibody |
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CAU25377-200ul | Biomatik Corporation | 200ul | EUR 278.9 |
Nitric Oxide Synthase Interacting Protein (NOSIP) Polyclonal Antibody |
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CAU28095-100ul | Biomatik Corporation | 100ul | EUR 211.2 |
Nitric Oxide Synthase Interacting Protein (NOSIP) Polyclonal Antibody |
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CAU28095-200ul | Biomatik Corporation | 200ul | EUR 263.8 |
Huntingtin-associated protein interacting protein (HAPIP) polyclonal antibody |
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ABP-PAB-10621 | Allele Biotech | 100 ug | Ask for price |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human), APC |
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4-PAE601Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2). This antibody is labeled with APC. |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human), Cy3 |
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4-PAE601Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2). This antibody is labeled with Cy3. |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human), FITC |
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4-PAE601Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2). This antibody is labeled with FITC. |
Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody (Human), HRP |
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4-PAE601Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Huntingtin Interacting Protein 2 (HIP2). This antibody is labeled with HRP. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Human) |
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4-PAJ086Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibrous Sheath Interacting Protein 1 (FSIP1) |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human, Mouse), FITC |
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4-PAC803Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Toll Interacting Protein (TOLLIP). This antibody is labeled with FITC. |
Huntingtin Interacting Protein 12 (HIP12) Polyclonal Antibody (Human, Pig) |
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4-PAC525Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Huntingtin Interacting Protein 12 (HIP12) |
Polyclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) |
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PAC859Ra01 | Cloud-Clone | 100ul | EUR 266 |
Toll Interacting Protein (TOLLIP) Polyclonal Antibody (Human), Biotinylated |
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4-PAC803Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Toll Interacting Protein (TOLLIP). This antibody is labeled with Biotin. |
Cannabinoid Receptor Interacting Protein 1 (CNRIP1) Polyclonal Antibody |
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CAU31731-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Cannabinoid Receptor Interacting Protein 1 (CNRIP1) Polyclonal Antibody |
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CAU31731-200ul | Biomatik Corporation | 200ul | EUR 294 |
Aryl Hydrocarbon Receptor Interacting Protein (AIP) Polyclonal Antibody |
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CAU24445-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Aryl Hydrocarbon Receptor Interacting Protein (AIP) Polyclonal Antibody |
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CAU24445-200ul | Biomatik Corporation | 200ul | EUR 294 |
Polyclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) |
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PAC525Hu01 | Cloud-Clone | 100ul | EUR 245 |
Rabbit Polyclonal antibody to Liprin alpha 1 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1) |
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TA308315 | Origene Technologies GmbH | 100 µl | Ask for price |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat), PE |
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4-PAJ086Ra01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with PE. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human), PE |
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4-PAR170Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with PE. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse), PE |
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4-PAR170Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with PE. |
Synuclein Alpha Interacting Protein 1 (SNCaIP1) Polyclonal Antibody (Rat) |
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4-PAC859Ra01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Synuclein Alpha Interacting Protein 1 (SNCaIP1) |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody (Human) |
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4-PAE898Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Catenin Beta Interacting Protein 1 (CTNNbIP1) |
Catenin Beta Interacting Protein 1 (CTNNbIP1) Polyclonal Antibody (Mouse) |
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4-PAE898Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Catenin Beta Interacting Protein 1 (CTNNbIP1) |
Polyclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) |
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PAF477Hu01 | Cloud-Clone | 100ul | EUR 245 |
Polyclonal Antibody to Glutamate Receptor Interacting Protein 1 (GRIP1) |
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PAB753Hu01 | Cloud-Clone | 100ul | EUR 232 |
Polyclonal Antibody to Glutamate Receptor Interacting Protein 1 (GRIP1) |
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PAB753Hu02 | Cloud-Clone | 100ul | EUR 232 |
Polyclonal Antibody to Nitric Oxide Synthase Interacting Protein (NOSIP) |
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PAA330Hu01 | Cloud-Clone | 100ul | EUR 220 |
Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) Polyclonal Antibody |
|||
CAU26274-100ul | Biomatik Corporation | 100ul | EUR 229.4 |
Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) Polyclonal Antibody |
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CAU26274-200ul | Biomatik Corporation | 200ul | EUR 287.3 |
Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) Polyclonal Antibody |
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CAU26275-100ul | Biomatik Corporation | 100ul | EUR 222.7 |
Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) Polyclonal Antibody |
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CAU26275-200ul | Biomatik Corporation | 200ul | EUR 278.9 |
Protein Interacting With C Kinase 1 (PICK1) Polyclonal Antibody |
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CAU26816-100ul | Biomatik Corporation | 100ul | EUR 217.9 |
Protein Interacting With C Kinase 1 (PICK1) Polyclonal Antibody |
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CAU26816-200ul | Biomatik Corporation | 200ul | EUR 272.2 |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Human), PE |
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4-PAJ086Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with PE. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat), APC |
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4-PAJ086Ra01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with APC. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat), Cy3 |
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4-PAJ086Ra01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with Cy3. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat), FITC |
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4-PAJ086Ra01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with FITC. |
Fibrous Sheath Interacting Protein 1 (FSIP1) Polyclonal Antibody (Rat), HRP |
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4-PAJ086Ra01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibrous Sheath Interacting Protein 1 (FSIP1). This antibody is labeled with HRP. |
Huntingtin Interacting Protein 12 (HIP12) Polyclonal Antibody (Human, Pig), PE |
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4-PAC525Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Huntingtin Interacting Protein 12 (HIP12). This antibody is labeled with PE. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human), APC |
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4-PAR170Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with APC. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human), Cy3 |
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4-PAR170Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with Cy3. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human), FITC |
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4-PAR170Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with FITC. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Human), HRP |
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4-PAR170Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with HRP. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse), APC |
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4-PAR170Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with APC. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse), Cy3 |
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4-PAR170Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with Cy3. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse), FITC |
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4-PAR170Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with FITC. |
Torsin A Interacting Protein 2 (TOR1AIP2) Polyclonal Antibody (Mouse), HRP |
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4-PAR170Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Torsin A Interacting Protein 2 (TOR1AIP2). This antibody is labeled with HRP. |
Homeodomain Interacting Protein Kinase 2 (HIPK2) Polyclonal Antibody (Human) |
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4-PAF477Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Homeodomain Interacting Protein Kinase 2 (HIPK2) |
Nitric Oxide Synthase Interacting Protein (NOSIP) Polyclonal Antibody (Human) |
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4-PAA330Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Nitric Oxide Synthase Interacting Protein (NOSIP) |
Notably, the overexpression of cyclin F(S621G) led to the aggregation and altered subcellular distribution of SFPQ in HEK293 cells, while resulting in altered degradation in major neurons. Overall, our knowledge hyperlinks ALS/FTD-causing mutations in CCNF to converging pathological options of ALS/FTD and supplies a hyperlink between faulty protein degradation programs and the pathological accumulation of a protein concerned in RNA processing and metabolism. Once generated in vivo, trans-3MGC acid is proposed to isomerize through a mechanism involving π electron delocalization with formation of a resonance construction that allows bond rotation.