Lung most cancers has the next incidence fee and mortality fee than all different cancers. Early prognosis and therapy of lung most cancers stay a serious problem, and the 5-year survival fee of its sufferers is barely 15%. Basic and scientific analysis, particularly the invention of biomarkers, is essential for enhancing the prognosis and therapy of lung most cancers sufferers. To establish novel biomarkers for lung most cancers, we used the iTRAQ8-plex labeling expertise mixed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate the serum and urine of sufferers with totally different phases of lung adenocarcinoma and wholesome people. A complete of 441 proteins had been recognized within the serum, and 1,161 proteins had been recognized within the urine.
The ranges of elongation issue 1-alpha 2, proteasome subunit alpha kind, and spermatogenesis-associated protein elevated considerably within the serum of sufferers with lung most cancers in contrast with these in wholesome controls. The ranges of transmembrane protein 143, cadherin 5, fibronectin 1, and collectin-11 decreased considerably within the serum of sufferers with metastases in contrast with these of nonmetastatic lung most cancers sufferers. In the urine of stage III and IV lung most cancers sufferers, the prostate-specific antigen and prostatic acid phosphatase decreased considerably, whereas neutrophil defensin 1 elevated considerably
. The outcomes of LC-MS/MS had been confirmed by enzyme-linked immunosorbent assay (ELISA) for transmembrane protein 143, cadherin 5, fibronectin 1, and collectin-11 within the serum. These proteins could also be a possible early prognosis and metastasis biomarkers for lung adenocarcinoma. Furthermore, the relative content material of these markers within the serum and urine could possibly be used to find out the development of lung adenocarcinoma and obtain correct staging and prognosis.
Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors
Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic targets in gastrointestinal stromal tumor (GIST), and therapy with the KIT/PDGFRA inhibitor imatinib is the usual of take care of sufferers with superior GIST. Polyclonal emergence of KIT/PDGFRA secondary mutations is the primary mechanism of imatinib development, making it difficult to beat KIT/PDGFRA-inhibitor resistance. It is unclear whether or not there are different therapeutic targets in superior GIST. Using genome-wide transcriptomic profiling of superior versus early-stage GIST and CRISPR knockout useful screens, we exhibit that CDK1 is often extremely expressed in superior GIST however not in early-stage GIST throughout three affected person cohorts. High expression of CDK1 was related to malignancy in GIST.
CDK1 was critically required for superior GIST, together with imatinib-resistant GIST. CDK1 ablation led to strong proliferation inhibition. A mass spectrometry-based proteomics display screen additional revealed that AKT is a novel substrate of CDK1 kinase in GIST. CDK1 certain AKT and controlled its phosphorylation, thereby selling GIST proliferation and development. Importantly, a pharmacological inhibitor of CDK1, RO-3306, disrupted GIST cell proliferation in CDK1 extremely expressed GIST however not in CDK1-negative GIST cells and non-transformed fibroblast cells.
Treatment with RO-3306 diminished tumor progress in each imatinib-resistant and imatinib-sensitive GIST xenograft mouse fashions. Our findings counsel that CDK1 represents a druggable therapeutic goal in GIST and warrants additional testing in scientific trials. Significant distinction in expression was noticed between vulnerable scientific and MDR strains, in addition to vulnerable scientific and environmental strains. Transition from an environmental saprophyte to a scientific pressure might alter its physiological traits to additional enhance its adaptation. This made it potential to enhance the selectivity within the willpower of these compounds in comparison with that obtained with conventional GC-MS ion sources.
Here, a brand new fuel chromatography-atmospheric strain photoionization-high-resolution mass spectrometry (GC-APPI-HRMS) technique mixed with selective pressurized liquid extraction (sPLE) has been developed for the selective willpower of Dechlorane Plus (DP) and its associated compounds in gull egg samples used as a bioindicator of contamination. To one of the best of our data, that is the primary time these compounds have been analyzed by GC-MS utilizing atmospheric strain photoionization (APPI). Negative ion dopant-assisted APPI utilizing vapors of diethyl ether and a supply temperature of 250 °C supplied excessive ionization efficiencies and mass spectra characterised by intense in-source fragment ions in addition to the presence of molecular ion and attribute cluster ions containing oxygen atoms of their chemical construction.
Proteomic profiling of scientific and environmental strains of Pseudomonas aeruginosa
Pseudomonas aeruginosa is a ubiquitous bacterium, which is ready to change its physiological traits in response to totally different habitats. Environmental strains are presumably much less pathogenic than scientific strains and whether or not or not the scientific strains originate from the atmosphere or by way of inter-host transmission stays poorly understood. To reduce the danger of an infection, a greater understanding of proteomic profiling of P. aeruginosa is critical for elucidating the correlation between environmental and scientific strains. Based on antimicrobial susceptibility and patterns of virulence, we chosen 12 scientific and environmental strains: (i) environmental, (ii) multidrug resistant (MDR) scientific and (iii) vulnerable scientific strains.
Total Protein Extraction Kit for Tendons (50 tests) |
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| P5A04 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Muscles (50 tests) |
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| P5A06 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Insects (50 tests) |
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| P5A07 | 101Bio | - | Ask for price |
Pro Total Protein Extraction Kit for Plant Tissues |
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| MBS9719245-50Tests | MyBiosource | 50Tests | EUR 270 |
Pro Total Protein Extraction Kit for Plant Tissues |
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| MBS9719245-5Tests | MyBiosource | 5Tests | EUR 160 |
Pro Total Protein Extraction Kit for Plant Tissues |
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| MBS9719245-5x50Tests | MyBiosource | 5x50Tests | EUR 1185 |
Total Protein Extraction Kit |
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| BSP003 | Bio Basic | 50Preps | EUR 130.99 |
Total Protein Extraction Kit |
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| K3011010 | Biochain | 1 kit | EUR 404 |
Total Protein Extraction Kit |
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| MBS2571976-100Assays | MyBiosource | 100Assays | EUR 270 |
Total Protein Extraction Kit |
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| MBS2571976-50Assays | MyBiosource | 50Assays | EUR 220 |
Total Protein Extraction Kit |
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| MBS2571976-5x100Assays | MyBiosource | 5x100Assays | EUR 1225 |
Total Protein Extraction Kit |
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| MBS9718634-200Tests | MyBiosource | 200Tests | EUR 290 |
Total Protein Extraction Kit |
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| MBS9718634-50Tests | MyBiosource | 50Tests | EUR 205 |
Total Protein Extraction Kit |
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| MBS9718634-5x200Tests | MyBiosource | 5x200Tests | EUR 1275 |
Total Protein Extraction Kit for Skin Tissue (50 tests) |
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| P5A01 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Bone Tissue (50 tests) |
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| P5A02 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Blood Vessels (50 tests) |
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| P5A03 | 101Bio | - | Ask for price |
MinuteTM Total Protein Extraction Kit for Tendons (50 tests) |
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| SA-04-TD | Inventbiotech | each | EUR 399 |
MinuteTM Total Protein Extraction Kit for Muscles (50 tests) |
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| SA-06-MS | Inventbiotech | each | EUR 399 |
MinuteTM Total Protein Extraction Kit for Insects (50 tests) |
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| SA-07-IS | Inventbiotech | each | EUR 399 |
Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| MBS9719101-50Tests | MyBiosource | 50Tests | EUR 250 |
Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| MBS9719101-5Tests | MyBiosource | 5Tests | EUR 160 |
Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| MBS9719101-5x50Tests | MyBiosource | 5x50Tests | EUR 1095 |
ExKine™ Pro Total Protein Extraction Kit for Plant Tissues |
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| KTP3008-each | Abbkine | each | Ask for price |
ExKine™ Pro Total Protein Extraction Kit for Plant Tissues |
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| KTP3008-50T | Abbkine | 50 T | EUR 219 |
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Description: ExKine™ Pro Total Protein Extraction Kit for Plant Tissues is a new generation of ultra-fast protein extraction tool that can efficiently extract total protein from plant tissues. |
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ExKine™ Pro Total Protein Extraction Kit for Plant Tissues |
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| KTP3008-5T | Abbkine | 5 T | EUR 39 |
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Description: ExKine™ Pro Total Protein Extraction Kit for Plant Tissues is a new generation of ultra-fast protein extraction tool that can efficiently extract total protein from plant tissues. |
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Mammalian Total Protein Extraction Kit |
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| 20-abx098853 | Abbexa |
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Mammalian Total Protein Extraction Kit |
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| abx098853-100l | Abbexa | 100 µl | EUR 437.5 |
Mammalian Total Protein Extraction Kit |
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| abx098853-1ml | Abbexa | 1 ml | Ask for price |
Mammalian Total Protein Extraction Kit |
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| abx098853-200l | Abbexa | 200 µl | Ask for price |
MinuteTM Total Protein Extraction Kit for Skin Tissue (50 tests) |
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| SA-01-SK | Inventbiotech | each | EUR 399 |
MinuteTM Total Protein Extraction Kit for Bone Tissue (50 tests) |
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| SA-02-BT | Inventbiotech | each | EUR 399 |
Total Protein Extraction Kit: 50X PI |
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| K3011010-2 | Biochain | 260 ul | EUR 301 |
MinuteTM Total Protein Extraction Kit for Blood Vessels (50 tests) |
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| SA-03-BV | Inventbiotech | each | EUR 399 |
Total Protein Extraction Assay Kit |
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| E-BC-E002-100Assays | Elabscience Biotech | 100 Assays | EUR 180 |
Total Protein Extraction Assay Kit |
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| E-BC-E002-50Assays | Elabscience Biotech | 50 Assays | EUR 1 |
Total Protein Extraction Assay Kit |
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| E-BC-E002-each | Elabscience Biotech | each | Ask for price |
Total Protein Extraction Kit for Intestines and Mesentery (50 tests) |
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| P5A05 | 101Bio | - | Ask for price |
ExKine™ Total Protein Extraction Kit |
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| KTP3006-each | Abbkine | each | Ask for price |
ExKine™ Total Protein Extraction Kit |
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| KTP3006-200T | Abbkine | 200 T | EUR 249 |
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Description: Abbkine ExKine™ Total Protein Extraction Kit is for lysis of mammalian cells and tissues. |
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ExKine™ Total Protein Extraction Kit |
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| KTP3006-50T | Abbkine | 50 T | EUR 109 |
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Description: Abbkine ExKine™ Total Protein Extraction Kit is for lysis of mammalian cells and tissues. |
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Total Protein Extraction Kit: TM Buffer |
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| K3011010-1 | Biochain | 13 ml | EUR 142 |
Minute TM Total Protein Extraction Kit for Plant Tissues (50 Tests) |
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| SD-008/SN-009 | Inventbiotech | each | EUR 330 |
Total Membrane Protein Extraction Kit |
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| MBS9718632-200Tests | MyBiosource | 200Tests | EUR 290 |
Total Membrane Protein Extraction Kit |
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| MBS9718632-50Tests | MyBiosource | 50Tests | EUR 205 |
Total Membrane Protein Extraction Kit |
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| MBS9718632-5x200Tests | MyBiosource | 5x200Tests | EUR 1275 |
Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes |
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| P522-20 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes |
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| P522-4 | 101Bio | - | Ask for price |
Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes |
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| P522-80 | 101Bio | - | Ask for price |
MinuteTM Total Protein Extraction Kit for Intestines and Mesentery (50 tests) |
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| SA-05-IM | Inventbiotech | each | EUR 399 |
3-min Bacterial Total Protein Extraction Kit |
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| P512L | 101Bio | - | Ask for price |
ExKine™ Pro Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| KTP3007-each | Abbkine | each | Ask for price |
ExKine™ Pro Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| KTP3007-50T | Abbkine | 50 T | EUR 179 |
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Description: Abbkine ExKine™ Pro Total Protein Extraction Kit for Animal Cultured Cells/Tissues provides a simple, rapid and reproducible method to extract total proteins. |
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ExKine™ Pro Total Protein Extraction Kit for Animal Cultured Cells/Tissues |
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| KTP3007-5T | Abbkine | 5 T | EUR 39 |
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Description: Abbkine ExKine™ Pro Total Protein Extraction Kit for Animal Cultured Cells/Tissues provides a simple, rapid and reproducible method to extract total proteins. |
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Total RNA Extraction Kit (For Tissue and Cell) |
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| MBS8245108-20Preps | MyBiosource | 20Preps | EUR 175 |
Total RNA Extraction Kit (For Tissue and Cell) |
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| MBS8245108-50Preps | MyBiosource | 50Preps | EUR 240 |
Total RNA Extraction Kit (For Tissue and Cell) |
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| MBS8245108-5x50Preps | MyBiosource | 5x50Preps | EUR 995 |
Total RNA Extraction Kit (For Serum and Plasma) |
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| MBS8245109-20Preps | MyBiosource | 20Preps | EUR 175 |
Total RNA Extraction Kit (For Serum and Plasma) |
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| MBS8245109-50Preps | MyBiosource | 50Preps | EUR 240 |
Total RNA Extraction Kit (For Serum and Plasma) |
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| MBS8245109-5x50Preps | MyBiosource | 5x50Preps | EUR 995 |
Plant Total Protein Extraction Reagent |
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| abx090633-50100assays | Abbexa | 50-100 assays | EUR 276 |
3-min Total Protein Extraction Kit (Animal cells) |
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| P501 | 101Bio | - | Ask for price |
3-min Total Protein Extraction Kit (Animal cells) |
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| P501L | 101Bio | - | Ask for price |
3-min Total Protein Extraction Kit (Animal cells) |
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| P501S | 101Bio | - | Ask for price |
8-min Plant Tissue Total Protein Extraction Kit |
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| P508L | 101Bio | - | Ask for price |
3-min Total Protein Extraction Kit (Animal Tissues) |
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| P502 | 101Bio | - | Ask for price |
3-min Total Protein Extraction Kit (Animal Tissues) |
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| P502L | 101Bio | - | Ask for price |
3-min Total Protein Extraction Kit (Animal Tissues) |
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| P502S | 101Bio | - | Ask for price |
Minute TM Total Protein Extraction Kit for Animal Cultured Cells/Tissues (50 Tests) |
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| SD-001/SN-002 | Inventbiotech | each | EUR 330 |
Total RNA Extraction Kit |
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| EP014-200T | ELK Biotech | 200T | EUR 164 |
Total RNA Extraction Kit |
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| EP014-50T | ELK Biotech | 50T | EUR 80 |
Total RNA Extraction Kit |
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| EP014 | ELK Biotech | 50T | EUR 164 |
Total RNA Extraction Kit |
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| MBS8808208-200Tests | MyBiosource | 200Tests | EUR 355 |
Total RNA Extraction Kit |
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| MBS8808208-50Tests | MyBiosource | 50Tests | EUR 250 |
ExKine™ Total Membrane Protein Extraction Kit |
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| KTP3004-each | Abbkine | each | Ask for price |
ExKine™ Total Membrane Protein Extraction Kit |
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| KTP3004-200T | Abbkine | 200 T | EUR 249 |
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Description: Abbkine ExKine™ Total Membrane Protein Extraction Kit provides a simple, rapid and reproducible method to extract total membrane proteins. |
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ExKine™ Total Membrane Protein Extraction Kit |
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| KTP3004-50T | Abbkine | 50 T | EUR 109 |
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Description: Abbkine ExKine™ Total Membrane Protein Extraction Kit provides a simple, rapid and reproducible method to extract total membrane proteins. |
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Bacterial Total Protein Extraction Reagent |
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| abx090632-50100assays | Abbexa | 50-100 assays | EUR 309.6 |
Bacterial Total Protein Extraction Reagent |
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| abx090632-100l | Abbexa | 100 µl | EUR 187.5 |
Bacterial Total Protein Extraction Reagent |
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| abx090632-1ml | Abbexa | 1 ml | Ask for price |
Bacterial Total Protein Extraction Reagent |
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| abx090632-200l | Abbexa | 200 µl | Ask for price |
Bacterial Total Protein Extraction Reagent |
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| MBS355474-50Tests | MyBiosource | 50Tests | EUR 235 |
Bacterial Total Protein Extraction Reagent |
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| MBS355474-5x50Tests | MyBiosource | 5x50Tests | EUR 755 |
Minute™ Total Protein Extraction Kit for Microbes with Thick Cell Walls (50 Tests) |
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| YT-015 | Inventbiotech | each | EUR 275 |
MinuteTM Total Protein Extraction Kit for Adipose Tissues/Cultured Adipocytes (20 Tests) |
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| AT-022 | Inventbiotech | each | EUR 435 |
Extract-EZ E1, Total Subcellular Protein Extraction Kit |
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| BSP073 | Bio Basic | 50Preps | EUR 162.31 |
AffiSelect Total Protein Extraction Solution |
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| A0710-015 | GenDepot | 15X1ml | EUR 170.4 |
SaMagTotal RNA Extraction kit For use with SaMag-12/24 instruments; extraction of total RNA from clinical specimens |
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| SM015 | Sacace Biotechnologies | 48 | EUR 274.68 |
Minute TM Bacterial Total Protein Extraction Kit (50 Tests) |
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| SB-004 | Inventbiotech | each | EUR 330 |
Minute TM Detergent-Free Total Protein Extraction Kit for Animal Cells/Tissues (50 Tests) |
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| SN-006 | Inventbiotech | each | EUR 399 |
Plant Total RNA Extraction Kit |
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| EP018-200T | ELK Biotech | 200T | EUR 325 |
Plant Total RNA Extraction Kit |
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| EP018-50T | ELK Biotech | 50T | EUR 106 |
Plant Total RNA Extraction Kit |
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| EP018 | ELK Biotech | 50T | EUR 325 |
Plant Total RNA Extraction Kit |
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| MBS8808211-200Tests | MyBiosource | 200Tests | EUR 585 |
Plant Total RNA Extraction Kit |
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| MBS8808211-50Tests | MyBiosource | 50Tests | EUR 280 |
AnaPrep Total RNA Extraction Kit |
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| Z1322015 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | EUR 295 |
10-min. Thick Cell Wall Microbes Total Protein Extraction Kit |
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| P515-50 | 101Bio | - | Ask for price |
Xpert Total Histone Extraction Kit |
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| H7200-050 | GenDepot | 50 ext | EUR 433.2 |
Xpert Total Histone Extraction Kit |
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| H7200-100 | GenDepot | 100 ext | EUR 610.8 |
EpiQuik Total Histone Extraction Kit |
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| OP-0006 | EpiGentek |
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3-min Detergent-free Total Protein Extraction Kit (Animal Cells) |
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| P505 | 101Bio | - | Ask for price |
8-min Plant Tissue Detergent-free Total Protein Extraction Kit |
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| P510L | 101Bio | - | Ask for price |
3-min Detergent-free Total Protein Extraction Kit (Animal Cells) |
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| P505L | 101Bio | 50 rxn | EUR 629 |
3-min Detergent-free Total Protein Extraction Kit (Animal Cells) |
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| P505S | 101Bio | 5 rxn | EUR 179 |
3-min Detergent-free Total Protein Extraction Kit (Animal Tissues) |
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| P506 | 101Bio | - | Ask for price |
3-min Detergent-free Total Protein Extraction Kit (Animal Tissues) |
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| P506L | 101Bio | 50 rxn | EUR 629 |
3-min Detergent-free Total Protein Extraction Kit (Animal Tissues) |
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| P506S | 101Bio | 5 rxn | EUR 179 |
Rapid Animal Total RNA Extraction Kit |
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| AT4181 | Bio Basic | 50Preps | EUR 105.67 |
Rapid Animal Total RNA Extraction Kit |
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| AT4182 | Bio Basic | 250preps | EUR 242.7 |
EpiQuik Total Histone Extraction HT Kit |
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| OP-0007 | EpiGentek |
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Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TR50 | GeneOn | 50 preps | EUR 253.2 |
Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TR96-05 | GeneOn | 5x96 preps | EUR 1084 |
Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TR05 | GeneOn | 5 preps | Ask for price |
Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TR100 | GeneOn | 100 preps | EUR 378 |
Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TR25 | GeneOn | 25 preps | EUR 176.4 |
Blood Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TB05 | GeneOn | 5 preps | Ask for price |
Blood Total RNA Extraction Kit (Proteinase K & DNase I included) |
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| TB25 | GeneOn | 25 preps | EUR 176.4 |
IBI ISOLATE TOTAL EXTRACTION REAGENT KIT |
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| IB47600 | IBI Scientific | 4ML | EUR 30.42 |
IBI ISOLATE TOTAL EXTRACTION REAGENT KIT |
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| IB47601 | IBI Scientific | 100ML (HAZ) | EUR 191.1 |
IBI ISOLATE TOTAL EXTRACTION REAGENT KIT |
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| IB47602 | IBI Scientific | 200ML (HAZ) | EUR 344.67 |
Total RNA Extraction Kit for Animal Tissue/ Cell , Centrifugal Colμmn Method, 50 |
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| 208111 | NEST Biotechnology | 8 pcs/cs | EUR 93.61 |
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Description: Total RNA Extraction Kit for Animal Tissue/ Cell , Centrifugal Colμmn Method, 50 reactions/pk |
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HiPer® Total RNA Extraction Teaching Kit |
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| HTBM012-10PR | EWC Diagnostics | 1 unit | EUR 58.31 |
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Description: HiPer® Total RNA Extraction Teaching Kit |
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xTractPure™ Cell Line Total RNA extraction Kit |
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| Z2212006 | Biochain | 1 kit (96 extractions) | EUR 499 |
TRIpure Total RNA Extraction Reagent |
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| EP013-100mL | ELK Biotech | 100mL | EUR 54 |
TRIpure Total RNA Extraction Reagent |
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| EP013-250mL | ELK Biotech | 250mL | EUR 93.5 |
TRIpure Total RNA Extraction Reagent |
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| EP013 | ELK Biotech | 100mL | EUR 93.5 |
TRIpure Total RNA Extraction Reagent |
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| MBS8820056-100mL | MyBiosource | 100mL | EUR 155 |
TRIpure Total RNA Extraction Reagent |
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| MBS8820056-250mL | MyBiosource | 250mL | EUR 200 |
BioLit Total RNA Extraction Kit from Plant (Research) |
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| 62606 | Sisco Laboratories | 50 Preps | EUR 196.71 |
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Description: Part E |
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EZ-10 Spin Column Viral Total RNA Extraction Kit |
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| VT82112 | Bio Basic | 50Preps | EUR 244.52 |
Whole-cell protein was extracted from every pressure and subjected to two-dimensional differential gel electrophoresis (2-D DIGE) and liquid chromatography tandem mass spectrometry quadrupole time-of-flight (LC-MS QTOF). All 12 strains had been clustered into three distinct teams primarily based on their variance in protein expression. A complete of 526 matched spots had been detected and 4 differentially expressed protein spots (p < 0.05) had been recognized and all differential spots had been downregulated in MDR pressure J3. Upregulation of chitin binding and BON area proteins was current within the environmental and a few MDR strains, whereas the scientific strains exhibited distinct proteomic profiles with elevated expression of serine protein kinase and arginine/ornithine transport ATP-binding proteins.