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LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer

LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer

Lung most cancers has the next incidence fee and mortality fee than all different cancers. Early prognosis and therapy of lung most cancers stay a serious problem, and the 5-year survival fee of its sufferers is barely 15%. Basic and scientific analysis, particularly the invention of biomarkers, is essential for enhancing the prognosis and therapy of lung most cancers sufferers. To establish novel biomarkers for lung most cancers, we used the iTRAQ8-plex labeling expertise mixed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate the serum and urine of sufferers with totally different phases of lung adenocarcinoma and wholesome people. A complete of 441 proteins had been recognized within the serum, and 1,161 proteins had been recognized within the urine.

The ranges of elongation issue 1-alpha 2, proteasome subunit alpha kind, and spermatogenesis-associated protein elevated considerably within the serum of sufferers with lung most cancers in contrast with these in wholesome controls. The ranges of transmembrane protein 143, cadherin 5, fibronectin 1, and collectin-11 decreased considerably within the serum of sufferers with metastases in contrast with these of nonmetastatic lung most cancers sufferers. In the urine of stage III and IV lung most cancers sufferers, the prostate-specific antigen and prostatic acid phosphatase decreased considerably, whereas neutrophil defensin 1 elevated considerably

. The outcomes of LC-MS/MS had been confirmed by enzyme-linked immunosorbent assay (ELISA) for transmembrane protein 143, cadherin 5, fibronectin 1, and collectin-11 within the serum. These proteins could also be a possible early prognosis and metastasis biomarkers for lung adenocarcinoma. Furthermore, the relative content material of these markers within the serum and urine could possibly be used to find out the development of lung adenocarcinoma and obtain correct staging and prognosis.

Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors

Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic targets in gastrointestinal stromal tumor (GIST), and therapy with the KIT/PDGFRA inhibitor imatinib is the usual of take care of sufferers with superior GIST. Polyclonal emergence of KIT/PDGFRA secondary mutations is the primary mechanism of imatinib development, making it difficult to beat KIT/PDGFRA-inhibitor resistance. It is unclear whether or not there are different therapeutic targets in superior GIST. Using genome-wide transcriptomic profiling of superior versus early-stage GIST and CRISPR knockout useful screens, we exhibit that CDK1 is often extremely expressed in superior GIST however not in early-stage GIST throughout three affected person cohorts. High expression of CDK1 was related to malignancy in GIST.

CDK1 was critically required for superior GIST, together with imatinib-resistant GIST. CDK1 ablation led to strong proliferation inhibition. A mass spectrometry-based proteomics display screen additional revealed that AKT is a novel substrate of CDK1 kinase in GIST. CDK1 certain AKT and controlled its phosphorylation, thereby selling GIST proliferation and development. Importantly, a pharmacological inhibitor of CDK1, RO-3306, disrupted GIST cell proliferation in CDK1 extremely expressed GIST however not in CDK1-negative GIST cells and non-transformed fibroblast cells.

Treatment with RO-3306 diminished tumor progress in each imatinib-resistant and imatinib-sensitive GIST xenograft mouse fashions. Our findings counsel that CDK1 represents a druggable therapeutic goal in GIST and warrants additional testing in scientific trials. Significant distinction in expression was noticed between vulnerable scientific and MDR strains, in addition to vulnerable scientific and environmental strains. Transition from an environmental saprophyte to a scientific pressure might alter its physiological traits to additional enhance its adaptation. This made it potential to enhance the selectivity within the willpower of these compounds in comparison with that obtained with conventional GC-MS ion sources.

Here, a brand new fuel chromatography-atmospheric strain photoionization-high-resolution mass spectrometry (GC-APPI-HRMS) technique mixed with selective pressurized liquid extraction (sPLE) has been developed for the selective willpower of Dechlorane Plus (DP) and its associated compounds in gull egg samples used as a bioindicator of contamination. To one of the best of our data, that is the primary time these compounds have been analyzed by GC-MS utilizing atmospheric strain photoionization (APPI). Negative ion dopant-assisted APPI utilizing vapors of diethyl ether and a supply temperature of 250 °C supplied excessive ionization efficiencies and mass spectra characterised by intense in-source fragment ions in addition to the presence of molecular ion and attribute cluster ions containing oxygen atoms of their chemical construction.

LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer

Proteomic profiling of scientific and environmental strains of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a ubiquitous bacterium, which is ready to change its physiological traits in response to totally different habitats. Environmental strains are presumably much less pathogenic than scientific strains and whether or not or not the scientific strains originate from the atmosphere or by way of inter-host transmission stays poorly understood. To reduce the danger of an infection, a greater understanding of proteomic profiling of P. aeruginosa is critical for elucidating the correlation between environmental and scientific strains. Based on antimicrobial susceptibility and patterns of virulence, we chosen 12 scientific and environmental strains: (i) environmental, (ii) multidrug resistant (MDR) scientific and (iii) vulnerable scientific strains.

Total Protein Extraction Kit

BSP003 50Preps
EUR 109.16
  • Product category: Molecular Biology Kits/Protein - Extraction/Animal

Mammalian Total Protein Extraction Kit

20-abx098853
  • EUR 356.00
  • EUR 105.00
  • 100 ml
  • 2 ml
  • Shipped within 5-10 working days.

Total RNA Extraction Kit

K2014005 1 kit
EUR 344
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein Extraction Kit for Tendons (50 tests)

P5A04 NULL
EUR 0

Total Protein Extraction Kit for Muscles (50 tests)

P5A06 NULL
EUR 0

Total Protein Extraction Kit for Insects (50 tests)

P5A07 NULL
EUR 0

Total Protein Extraction Kit: TM Buffer

K3011010-1 13 ml
EUR 162
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein Extraction Kit: 50X PI

K3011010-2 260 ul
EUR 289
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein Extraction Kit for Skin Tissue (50 tests)

P5A01 NULL
EUR 0

Total Protein Extraction Kit for Bone Tissue (50 tests)

P5A02 NULL
EUR 0

Total Protein Extraction Kit for Blood Vessels (50 tests)

P5A03 NULL
EUR 0

Xpert Total Histone Extraction Kit

H7200-050 50 ext
EUR 361

Xpert Total Histone Extraction Kit

H7200-100 100 ext
EUR 509

EpiQuik Total Histone Extraction Kit

OP-0006 100 Extractions
EUR 225.45
Description: The best epigenetics products

AnaPrep Total RNA Extraction Kit

Z1322015 1 kit (48 extractions) Including all required plastic disposables
EUR 308
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

AffiSelect Total Protein Extraction Solution

A0710-015 15X1ml
EUR 142

Bacterial Total Protein Extraction Reagent

abx090632-50100assays 50-100 assays
EUR 258
  • Shipped within 5-10 working days.

Plant Total Protein Extraction Reagent

abx090633-50100assays 50-100 assays
EUR 230
  • Shipped within 5-10 working days.

Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes

P522-20 NULL
EUR 0

Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes

P522-4 NULL
EUR 0

Total Protein Extraction Kit for Adipose Tissues and Cultured Adipocytes

P522-80 NULL
EUR 0

Total Protein Extraction Kit for Intestines and Mesentery (50 tests)

P5A05 NULL
EUR 0

3-min Bacterial Total Protein Extraction Kit

P512L NULL
EUR 0

Human Total PSA (t-PSA) ELISA Kit

PRB-5049-TOTAL 96 assays
EUR 572

EpiQuik Total Histone Extraction HT Kit

OP-0007 192 Extractions
EUR 395.1
Description: reagents widely cited

Rapid Animal Total RNA Extraction Kit

AT4181 50Preps
EUR 88.06
  • Product category: Molecular Biology Kits/RNA - Extraction/Animal

Rapid Animal Total RNA Extraction Kit

AT4182 250preps
EUR 202.25
  • Product category: Molecular Biology Kits/RNA - Extraction/Animal

Trypin for Mass & Sequencing

T9600-025 25ug
EUR 145

Trypin for Mass & Sequencing

T9600-100 100ug
EUR 219

Trypin for Mass & Sequencing

T9600-112 12x100ug
EUR 1657

Trypin for Mass & Sequencing

T9600-400 4x100ug
EUR 651

3-min Total Protein Extraction Kit (Animal cells)

P501 NULL
EUR 0

3-min Total Protein Extraction Kit (Animal cells)

P501L NULL
EUR 0

3-min Total Protein Extraction Kit (Animal cells)

P501S NULL
EUR 0

3-min Total Protein Extraction Kit (Animal Tissues)

P502 NULL
EUR 0

3-min Total Protein Extraction Kit (Animal Tissues)

P502L NULL
EUR 0

3-min Total Protein Extraction Kit (Animal Tissues)

P502S NULL
EUR 0

8-min Plant Tissue Total Protein Extraction Kit

P508L NULL
EUR 0

Extract-EZ E1, Total Subcellular Protein Extraction Kit

BSP073 50Preps
EUR 135.26
  • Product category: Molecular Biology Kits/Protein - Extraction/Animal

Human Total PSA (t-PSA) ELISA Kit

PRB-5049-TOTAL-5 5 x 96 assays
EUR 2283

RNA isolater Total RNA Extraction Reagent

R401-01 100 ml
EUR 133

AnaPrep Total RNA Extraction Kit with DNase-Treatment

Z1322017 1 kit (48 extractions) Including all required plastic disposables
EUR 405
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

3-min Detergent-free Total Protein Extraction Kit (Animal Cells)

P505 NULL
EUR 0

3-min Detergent-free Total Protein Extraction Kit (Animal Cells)

P505L NULL
EUR 0

3-min Detergent-free Total Protein Extraction Kit (Animal Cells)

P505S NULL
EUR 0

3-min Detergent-free Total Protein Extraction Kit (Animal Tissues)

P506 NULL
EUR 0

3-min Detergent-free Total Protein Extraction Kit (Animal Tissues)

P506L NULL
EUR 0

3-min Detergent-free Total Protein Extraction Kit (Animal Tissues)

P506S NULL
EUR 0

8-min Plant Tissue Detergent-free Total Protein Extraction Kit

P510L NULL
EUR 0

10-min. Thick Cell Wall Microbes Total Protein Extraction Kit

P515-50 NULL
EUR 0

Total RNA Extraction Kit (Proteinase K & DNase I included)

TR05 5 preps Ask for price

Total RNA Extraction Kit (Proteinase K & DNase I included)

TR100 100 preps
EUR 315

Total RNA Extraction Kit (Proteinase K & DNase I included)

TR25 25 preps
EUR 147

Total RNA Extraction Kit (Proteinase K & DNase I included)

TR50 50 preps
EUR 211

EZ-10 Spin Column Viral Total RNA Extraction Kit

VT82112 50Preps
EUR 203.77
  • Product category: Molecular Biology Kits/RNA - Extraction/Viral

Triton Extraction Buffer(TEB), for Histon Extraction

T8300-100 100ml
EUR 126

Triton Extraction Buffer(TEB), for Histon Extraction

T8300-500 500ml
EUR 142

Total Exosome RNA Extraction Kit (Biological Fluids/Culture Media Supplement)

EIRK-03 20 reactions
EUR 2817
Description: This product is a useful tool for the isolation and efficient total RNA (miRNA and mRNAs) extraction from the total exosome population from human biofluids or cell culture media.

Blood Total RNA Extraction Kit (Proteinase K & DNase I included)

TB05 5 preps Ask for price

Blood Total RNA Extraction Kit (Proteinase K & DNase I included)

TB25 25 preps
EUR 147

Membrane Protein Extraction Kit

55R-1357 50 assays
EUR 740
Description: Membrane Protein Extraction Kit for use in the research laboratory

Membrane Protein Extraction Kit

K268-50
EUR 539

Membrane Protein Extraction Kit

K3014005 1 kit
EUR 382
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein Extraction Kit

K2113-50 50 assays
EUR 544

Plant Protein Extraction Kit

BSP004 20Preps
EUR 110.9
  • Product category: Molecular Biology Kits/Protein - Extraction/Plant

Nuclear Protein Extraction Kit

BSP009 50Preps
EUR 89.15
  • Product category: Molecular Biology Kits/Protein - Extraction/Animal

FFPE Protein Extraction Kit

BSP058 50Preps
EUR 102.2
  • Product category: Molecular Biology Kits/Protein - Extraction/FFPE Tissue

DNA Extraction Buffer for wells

D105 30 ml
EUR 204
  • Product category: DNA and RNA extraction and purification
Description: DNA Extraction Buffer for wells by Cygnus Technologies is available in Europe via Gentaur.

DNA Extraction Buffer for tubes

D108 30 ml
EUR 204
  • Product category: DNA and RNA extraction and purification
Description: DNA Extraction Buffer for tubes by Cygnus Technologies is available in Europe via Gentaur.

Viral RNA Extraction Kit for Respiratory Specimens

K1462-250 250 Rxns
EUR 1006

Viral RNA Extraction Kit for Respiratory Specimens

K1462-50 50 Rxns
EUR 399

Protein Extraction for Fixed and Embedded Tissues

P525-20 NULL
EUR 0

Protein Extraction Kit for Hair, Nail, Wool and Horn

P521-20 NULL
EUR 0

Protein Extraction Kit for Hair, Nail, Wool and Horn

P521-4 NULL
EUR 0

Protein Extraction Kit for Hair, Nail, Wool and Horn

P521-80 NULL
EUR 0

ExoDNA? Extraction Kit

K1242-25
EUR 588

ExoDNA? Extraction Kit

K1242-50
EUR 881

miRNA Extraction Kit

K1456-50 50 Preps
EUR 551

ELISA kit for Mouse Legumain (total)

EK5744 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Legumain (total) in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Total IgE

KTE62846-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Total IgE in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Total IgE

KTE62846-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Total IgE in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Total IgE

KTE62846-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Total IgE in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Total Carnitine

KTE100967-48T 48T
EUR 354
  • Carnitine (?-hydroxy-?-N-trimethylaminobutyric acid, 3-hydroxy-4-N,N,N- trimethylaminobutyrate) is a quaternary ammonium compound involved in metabolism in most mammals, plants and some bacteria. Carnitine may exist in two isomers, labeled D-carnitin
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Total Carnitine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Total Carnitine

KTE100967-5platesof96wells 5 plates of 96 wells
EUR 2252
  • Carnitine (?-hydroxy-?-N-trimethylaminobutyric acid, 3-hydroxy-4-N,N,N- trimethylaminobutyrate) is a quaternary ammonium compound involved in metabolism in most mammals, plants and some bacteria. Carnitine may exist in two isomers, labeled D-carnitin
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Total Carnitine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Total Carnitine

KTE100967-96T 96T
EUR 572
  • Carnitine (?-hydroxy-?-N-trimethylaminobutyric acid, 3-hydroxy-4-N,N,N- trimethylaminobutyrate) is a quaternary ammonium compound involved in metabolism in most mammals, plants and some bacteria. Carnitine may exist in two isomers, labeled D-carnitin
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Total Carnitine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Horse TOTAL PROTEIN(TOTAL PROTEIN)

QY-E120081 96T
EUR 478

Mammalian Membrane Protein Extraction Kit

AR0155 1 kit
EUR 152

Mammalian Membrane Protein Extraction Kit

20-abx098855
  • EUR 105.00
  • EUR 384.00
  • 2 rxns
  • 50 rxns
  • Shipped within 5-10 working days.

CNM Compartmental Protein Extraction Kit

K3012010 1 kit
EUR 412
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

CNMCS Compartmental Protein Extraction Kit

K3013010 1 kit
EUR 496
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Prolytic Membrane Protein Extraction Kit

P6300-020 20 prep
EUR 266

Prolytic Membrane Protein Extraction Kit

P6300-050 50 prep
EUR 469

Serum Exosomal Protein Extraction kit

P300 NULL
EUR 0

Serum Exosomal Protein Extraction kit

P300S NULL
EUR 0

Xpert Plant Protein Extraction Kit

P3113-050 50 Prep
EUR 550

Inclusion Body Protein Extraction Kit

BS686 1kit, 10prep
EUR 106.55
  • Product category: Molecular Biology Kits/Protein - Extraction/Inclusion Bodies

ELISA kit for Human Total protein S (TPS)

KTE62685-48T 48T
EUR 332
  • TPS is the specific M3 epitope of TPA has been used as a prognostic parameter for some neoplasms since it was isolated in the serum or urine of some cancer patients.TPS is most frequently elevated in malignant tissues. Serum TPS levels not only refl
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Total protein S (TPS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Total protein S (TPS)

KTE62685-5platesof96wells 5 plates of 96 wells
EUR 2115
  • TPS is the specific M3 epitope of TPA has been used as a prognostic parameter for some neoplasms since it was isolated in the serum or urine of some cancer patients.TPS is most frequently elevated in malignant tissues. Serum TPS levels not only refl
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Total protein S (TPS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Total protein S (TPS)

KTE62685-96T 96T
EUR 539
  • TPS is the specific M3 epitope of TPA has been used as a prognostic parameter for some neoplasms since it was isolated in the serum or urine of some cancer patients.TPS is most frequently elevated in malignant tissues. Serum TPS levels not only refl
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Total protein S (TPS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Total protein C (TPC)

KTE70657-48T 48T
EUR 354
  • Proc encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The protein C undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Total protein C (TPC) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Total protein C (TPC)

KTE70657-5platesof96wells 5 plates of 96 wells
EUR 2252
  • Proc encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The protein C undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Total protein C (TPC) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Total protein C (TPC)

KTE70657-96T 96T
EUR 572
  • Proc encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The protein C undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Total protein C (TPC) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Miniprep Kit For Plasmid DNA Extraction And Purification

MB1005-100Reactions 100 Reactions
EUR 143

Miniprep Kit For Plasmid DNA Extraction And Purification

MB1005-250Reactions 250 Reactions
EUR 259

Miniprep Kit For Plasmid DNA Extraction And Purification

MB1005-50Reactions 50 Reactions
EUR 120

AnaPrep HPV DNA Extraction Kit for swab samples

Z1322007 1 kit (48 extractions) Including all required plastic disposables
EUR 276
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (50prep)

FAFFM-050 50 preps
EUR 165

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (100prep)

FAFFM-100 100 preps
EUR 224

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

Monkey Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx360252-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Pig Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx361997-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx362317-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Human Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx351643-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.

Chicken Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx356091-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Cow Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515621-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Dog Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515622-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Human Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515623-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Mouse Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515624-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Pig Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515625-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Rat Low Molecular Mass Protein 7 (PSMB8) ELISA Kit

abx515626-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110
  • Category: Cas9

Monoclonal antibody for HSP90 (total)

SMC-149A 0.05mg
EUR 205
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is not conjugated.

Monoclonal antibody for HSP90 (total)

SMC-149B 0.2mg
EUR 366
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is not conjugated.

Monoclonal antibody for HSP90 (total)

SMC-149B-A390 0.2mg
EUR 456
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 390.

Monoclonal antibody for HSP90 (total)

SMC-149B-A488 0.2mg
EUR 453
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 488.

Monoclonal antibody for HSP90 (total)

SMC-149B-A565 0.2mg
EUR 453
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 565.

Monoclonal antibody for HSP90 (total)

SMC-149B-A594 0.2mg
EUR 453
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Mouse | Rat HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 594.

Monoclonal antibody for HSP90 (total)

SMC-149B-A633 0.2mg
EUR 453
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Rat | Rainbow Trout (Oncorhynchus mykiss) HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 633.

Monoclonal antibody for HSP90 (total)

SMC-149B-A655 0.2mg
EUR 453
  • HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms ? and ?, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). De
  • Show more
Description: A monoclonal antibody from clone 4F3.E8 against Human | Rat | Rainbow Trout (Oncorhynchus mykiss) HSP90 (total). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Recombinant Human HSP90 purified from E.coli. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:2000), IHC (1:100), ICC/IF (1:100). This MAb for HSP90 (total) is conjugated with ATTO 655.

Whole-cell protein was extracted from every pressure and subjected to two-dimensional differential gel electrophoresis (2-D DIGE) and liquid chromatography tandem mass spectrometry quadrupole time-of-flight (LC-MS QTOF). All 12 strains had been clustered into three distinct teams primarily based on their variance in protein expression. A complete of 526 matched spots had been detected and 4 differentially expressed protein spots (p < 0.05) had been recognized and all differential spots had been downregulated in MDR pressure J3. Upregulation of chitin binding and BON area proteins was current within the environmental and a few MDR strains, whereas the scientific strains exhibited distinct proteomic profiles with elevated expression of serine protein kinase and arginine/ornithine transport ATP-binding proteins.